A modified comorbidity index for hematopoietic cell transplantation

Hematopoietic Stem Cell Transplantation for Thalassemia

Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

Pediatric Hematopoietic Stem Cell Transplantation

The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

Hematopoietic Cell Transplantation-Specific Comorbidity Index: A New Tool for Risk Assessment Before Allogeneic HCT

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT.

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the CCI, did not exceed 35%. Further, some comorbidities were rarely found among patients who underwent HCT. Therefore, the current study was desi...

Modified Charlson comorbidity index for predicting survival after liver transplantation.

The benefit of liver transplantation (LT) is determined not only by the severity of illness, but also by the likelihood of posttransplantation survival. Current models are unable to accurately predict which patients will have the best posttransplant survival. We hypothesized that the Charlson Comorbidity Index (CCI), which includes nine comorbidities, could be used to predict survival after LT....